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Doxycycline is a broad-spectrum antibiotic synthetically derived from oxytetracycline and they are available in three forms;100 mg, 75 mg, and 50 mg capsules contain doxycycline monohydrate equivalent to 100 mg, 75 mg, or 50 mg of doxycycline for oral administration.This drug has a high degree of lipid solubility and a low affinity for calcium binding. It is highly stable in normal human serum and Doxycycline will not degrade into an epianhydro form.
Inert ingredients: hard gelatin capsule which contains black iron oxide, red iron oxide, titanium dioxide, colloidal silicon dioxide and yellow iron oxide for the 100 mg and 75 mg strengths, titanium dioxide and yellow iron oxide for the 50 mg strength; magnesium stearate; microcrystalline cellulose; and sodium starch glycolate.
To reduce the development of drug-resistant bacteria and maintain effectiveness of Doxycycline and other antibacterial drugs, this drug should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, doxycycline should be considered in selecting or modifying antibacterial therapy This drug is indicated for the treatment of the following infections: Rocky mountain spotted fever, typhus fever and the typhus group, Q fever,rickettsialpox, and tick fevers caused by Rickettsia, Respiratory tract infections caused by Mycoplasma pneumoniae,Lymphogranuloma venereum caused by Chlamydia trachomatis, Psittacosis (ornithosis) caused by Chlamydia psittaci, Trachoma caused by Chlamydia trachomatis, although the infectious agent is not always eliminated as judged by immunofluorescence.
Inclusion conjunctivitis caused by Chlamydia trachomatis, uncomplicated urethral, endocervical or rectal infections in adults caused by Chlamydia trachomatis,Nongonococcal urethritis caused by Ureaplasma urealyticum and Relapsing fever due to Borrelia recurrentis.
Doxycycline is also the drug of choice in treating infections caused by the following gram-negative microorganisms: Plague due to Yersinia pestis, Tularemia due to Francisella tularensis, Cholera caused by Vibrio cholerae Campylobacter fetus infections caused by Campylobacter fetus and Brucellosis due to Brucella species.
Because many strains of the following groups of microorganisms have been shown to be resistant to the said drug, culture and susceptibility testing are recommended.
Doxycycline is indicated for treatment of infections caused by the following gram-negative microorganisms, when bacteriologic testing indicates appropriate susceptibility to the drug: Escherichia coli, Enterobacter aerogenes, Shigella species ,Acinetobacter species (formerly Mima species and Herellea species), Respiratory tract infections caused by Haemophilus influenzae and Respiratory tract and urinary tract infections caused by Klebsiella species. Doxycycline is indicated for treatment of infections caused by the following gram-positive microorganisms when bacteriologic testing indicates appropriate susceptibility to the drug:
Upper respiratory infections caused by Streptococcus pneumoniae or skin and skin structure infections caused by Staphylococcus aureus.